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Diffuse large B cell lymphoma (DLBCL) - Management and Treatment Algorithm

By Matthew Ho, MD PhD @MatthewHoMD

#Diffuse
Diffuse large B cell ... lymphoma (DLBCL) - Management ... and Treatment Algorithm ... #Treatment #Algorithm ... #oncology #hematology
Spontaneous Bacterial Peritonitis 
Clinical 
 • Fever 
 • Chills 
 • Abdominal pain 
Diagnosis
Clinical • Fever ... • Chills • Abdominal ... stain/culture Management ... SBP #Diagnosis #Hepatology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Acute sickle cell ... hepatic crisis: • Fever ... Supportive with treatment ... cholestasis: • Fever ... Hepatobiliary #hepatology
Diagnostic criteria for Neutropenic Enterocolitis (NEC)
Major Criteria:
 • Neutropenia (ANC <500 x 10^9 cells/L)
 • Bowel
30mm length) • Fever ... Criteria: • Abdominal ... distention • Abdominal ... Diagnosis #criteria #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... , weight loss, abdominal ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
megaloblastic anemia Treatment ... Consider stem cell ... if neutropenic fever ... Anemia #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... Allogeneic stem cell ... only curative treatment ... #treatment #hematology ... #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
- Pel-Ebstein fever ... the spleen or liver ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
in those with CLD ... months without treatment ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
incompetent • CLL ... Lymphadenopathy • Fevers ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology