21 results
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG)
SAAG ≥ 1.1:
 - Ascitic protein
albumin gradient ... syndrome, Massive liver ... #albumin #gradient ... #hepatology #differential ... #diagnosis #algorithm
Deciphering the SAAG - Serum to Ascites Albumin Gradient
Ascites is either made in the liver sinusoid
made in the liver ... or not by the liver ... the blood The diseased ... liverprof #Diagnosis #Hepatology ... Interpretation #Differential
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis
High albumin gradient (>1.1 g/dl):
 - Cirrhosis	
 - Alcoholic
Serum Ascites Albumin ... Gradient (SAAG) - Differential ... - Acute fatty ... #Differential # ... Diagnosis #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Veno-occlusive disease ... Liver disease ... fibrosis - Acute ... Causes #diagnosis #differential ... #hepatology #SAAG
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
- Differential ... Diagnosis Algorithm ... • Infiltrative disease ... • Acute liver ... #Hepatology #causes
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... of portal HTN: ascites ... INR, bilirubin, albumin ... • Cirrhosis/acute ... Diagnosis #causes #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Hepatocellular Level ... Production: • Albumin ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes