11 results
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Cirrhosis - Diagnosis Algorithm ... Symptoms: Fatigue ... quadrant discomfort Signs ... Liver biopsy findings ... #hepatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... levels, greater level ... less systemic symptoms ... anti-synthetase syndrome ... Myositis #diagnosis #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... - 80% have fever ... WBC >100k, + lab signs ... diagnosis #management #hematology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
tests algorithm ... suspicious clinical symptoms ... /signs should be ... presence of metabolic syndrome ... #Hepatology #Liver
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... Diagnosis: HLH signs ... and symptoms can ... following: • Fever ... management #treatment #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... Diagnosis: >3 symptoms ... Differentiation #Syndrome ... diagnosis #management #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Symptoms ... associated with autoimmune ... thrombophlebitis, pulmonary ... Antiphospholipid syndrome ... #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Coronary arteries - Fever ... • Cogan Syndrome ... Presentation - Systemic Symptoms ... purpura: strong sign ... differential #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology