48 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... #Management #Hematology
Here is a quick guide on the common direct-acting antivirals (DAAs) for chronic hepatitis C virus
Antivirals #table #treatment ... #medications #infectiousdisease ... #hepatology #HepC ... HepatitisC #Management #Pharmacology
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
Pneumonia - Typhoid fever ... respiratory distress syndrome ... Corticosteroids #Adjuvant #InfectiousDiseases ... #Infections #Pharmacology ... #Management #Treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
- Virtually never ... adverse effects = Hematologic ... Thrombocytopenia) and Hepatic toxicity ... monitored to reduce toxicity ... #Pharmacology #Antibiotics
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... , ↓ Fibrinogen level ... Unknown cause Treatment ... #summary #rheumatology
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
Cardiopulmonary Syndrome ... • Prodrome: fever ... • Autopsy PCR Treatment ... diagnosis #management #treatment ... #microbiology #infectiousdiseases
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
sequestration and activation ... explain symptoms • Fever ... : 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... : • Treatment: ... Behcets #disease #Syndrome ... #pharmacology # ... rheumatology
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Oroya Fever Hematologic ... Inflammation: high fever ... coinfection, toxo reactivation ... TREATMENT: ​• Acute ... gabrieltalledop #Oroya #Fever