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diagnosis management hematology hemophagocytic hlh infections lymphohistiocytosis medications nephrology table adjuvant algorithm amiodarone antipsychotic apml calcium cancer cardiology comparison corticosteroids
Adjuvant therapies in critical care: steroids to treat infectious diseases - Severe Community Acquired Pneumonia
ventilation, ARDS acute ... respiratory distress syndrome ... Corticosteroids #Adjuvant #InfectiousDiseases ... #Infections #Pharmacology ... #Management #Treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... presents as an acute ... • Bicytopenia Treatment ... #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
sequestration and activation ... : 33% • Treatment ... At least 3 of (Acute ... : No • Treatment ... Transfusion #Reactions #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, acute ... organ damage • Treatment ... Low calcium • Treatment ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Common: fever ... Renal Failure Treatment ... Differentiation #Syndrome
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Medication/Drug toxicity ... , ADEM, Acute toxic ... elevated protein level ... persistent altered level ... epilepticus Treatment
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... Diuresis #Nephrology #Pharmacology
Neurological Side Effects of Antipsychotic Drugs Acute dystonia - Spasm of muscles of tongue, face, neck, back
Antipsychotic Drugs Acute ... Extreme rigidity, fever ... tremor ("rabbit syndrome ... months or years of treatment ... #SideEffects #pharmacology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
presents with acute ... pulmonary symptoms • Rheumatologic ... Increased protein level ... normal glucose level ... ) #Mycoses #InfectiousDiseases
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