14 results
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... #gastroenterology ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
UGT1A1 activity level ... of hemolysis or liver ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... ↑ AST ↑ ALT ↑ bilirubin ... #Hematology #Rheumatology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... death Neutropenic Fever ... Superior Vena Cava Syndrome ... : Tumor Lysis Syndrome
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... #hepatology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
Algorithm regarding ... and hematologic ... hemochromatosis #algorithm ... #diagnosis #management ... #hepatology #gastroenterology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Symptoms: - Fever ... arthralgia) - Fever ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... and petechiae Causes ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... - 80% have fever ... TLS #diagnosis #management ... #hematology