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Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential Diagnosis ... Hyperviscosity Syndrome ... death Neutropenic Fever ... New-onset back pain ... #differential #diagnosis
Dressler Syndrome - 
Postmyocardlal Infarctlon syndrome / Postpericardlotomy pericarditis
• Occurs 2 -10 weeks post myocardial infarction
Dressler Syndrome ... Persistent low-grade fever ... • Chest pain ( ... #Dressler #Syndrome ... #Diagnosis #Cardiology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
symptoms are not caused ... e.g. incidental CXR ... General: fever, ... : ACUTE, fever, ... presentation with fever
Bradycardia - Differential Diagnosis Framework

BRADI Mnemonic
 • BRASH/Hyperkalemia
 • Reduced oxygen/Glucose/Temp
 • ACS
 • Drugs
 •
Diptheria • Typhoid fever ... Acute rheumatic fever ... Psittacosis • Q fever ... • Yellow fever ... #causes #cardiology
Campylobacter
Clinical 
 • Fever 
 • Abdominal pain 
 • Diarrhea (bloody stools) 
 • Vomiting
Clinical • Fever ... • Abdominal pain ... Guillain-Barré syndrome ... Management ... Campylobacter #Diagnosis
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... abdomen if abdominal pain ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Fever: • Regulated ... BrighamChiefs #Fever ... Hyperthermia #comparison #diagnosis ... #management #treatment
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
- Differential Diagnosis ... Pneumonia: • 3 syndromes ... • Fever, weight ... of a "flu-like syndrome ... #differential #diagnosis
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Symptoms: - Fever ... arthralgia) - Fever ... #oncology
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Diagnosis Framework ... Bone/Joint Causes ... syndrome • Arthritis ... /swelling - Fever ... #differential #diagnosis