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oncology pregnancy aflp thrombocytopenia treatment comparison differential hellp obgyn table ttphus activation anemia aplastic apml calcium classification common cppd cvid
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
TTP/HUS, HELLP Syndrome ... and Acute Fatty Liver ... Pregnancy (AFLP) Three syndromes ... #HELLP #AFLP #obstetrics ... #hematology #diagnosis
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... Hemolysis, Elevated Liver ... #HELLP #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
AP, ↑INR, ↑BUN/Cr ... ) Differential Diagnosis ... #Pregnancy #hepatology ... #obstetrics #obgyn ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... - 80% have fever ... acid, Elevated Cr ... #TLS #diagnosis ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... syndromes Clinical ... hypersensitivity syndromes ... #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Subacute-Acute: • Common: fever ... common • Imaging: CXR ... Differentiation #Syndrome ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... following: • Fever ... lymph node, or liver ... #management #treatment ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Low serum IgG level ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Presentation: • Fever ... index < 2 • EPO Level ... Anemia #oncology #hematology ... #diagnosis #management
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
insufficiency (Cr ... or doubling of Cr ... patients • HELLP: Syndrome ... hypertension #htn #obstetrics ... #cardiology #differential
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