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diagnosis management acute classification differential nephrology rheumatology activation algorithm aplastic b12 cancer causes cell cobalamin deficiency dili druginduced drugs erythematosus
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... change disease • Hematologic ... malignancies Treatment ... #Injury #AKI #Cancer ... #Oncology #Differential
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing ... Acute Kidney Injury ... , tenofovir • AIN ... #Injury #Medications ... #Drugs #pharmacology
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... interstitial nephritis (AIN ... tract infection • Medications ... #Acute #Kidney
Acute Kidney Injury (AKI) - Management Principles Prerenal - Correct hemodynamic derangements: • If low preload →
Acute Kidney Injury ... (AKI) - Management ... Treat underlying liver ... • AIN → Consider ... #Injury #treatment
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Skin involvement, Kidney ... duration), Several medications ... non-essential drug/HDS treatments ... #Algorithm #hepatology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
symptoms: - Muscle pain ... - Abdominal pain ... declines > ALT) • AKI ... + myoglobin AKI ... nephrotoxicity to kidney
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... - Antithyroid medications ... index < 2 • EPO Level ... Treatment: ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
is the main clinical ... Heart, lung, and kidney ... with leukopenia, anemia ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
: • Vit B12 - aka ... gastric acidity, medications ... GI - glossitis (pain ... of tongue), abd pain ... Check for IF ab Treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Arthritis: • Joint pain ... lymphopenia, low PLT • Anemia ... C4) • ds-DNA: Kidney ... induced SLE • Kidney ... activation and/or medications
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