37 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... Diagnosis and Treatment ... Algorithm Matthew ... #HES #Hematology ... diagnosis #management #algorithm
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Pathogenesis and clinical ... Anterior Cord Syndrome ... injury, often from vascular ... • Central Cord Syndrome ... signs #symptoms #msk
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... syndromes Clinical ... is the main clinical ... Treatment: • Corticosteroids ... #Rheumatology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Insufficiency, Liver ... Abdominal compartment syndrome ... , Vascular compression ... #criticalcare #algorithm ... #treatment #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... triad: Fever, Arthralgia ... abnormalities • Muscular ... diagnosis #management #treatment ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Cathepsin G release → vascular ... Renal Failure Treatment ... Differentiation #Syndrome
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Vascular Sludging ... : • Clinical triad ... rheumatoid factor level ... C4 complement level ... classification #rheumatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary
A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... intrapulmonary vascular ... shunt (Type 2) Clinical ... Intra-pulmonary vascular ... ) on room air Treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... Presentation: • Fever ... index < 2 • EPO Level ... aplastic anemia Treatment ... Anemia #oncology #hematology