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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Microangiopathies #Systemic ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Petechial or purpuric rash ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Anti-phospholipid) M Malar Rash ... D Discoid Rash ... Pleuritis) H Hematologic ... IMDAMNSHARP #sle #systemic ... erythematosus #rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
levels, greater level ... weakness, less systemic ... can present with rash ... including heliotrope rash ... after 2 years of treatment
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... Medicine @SCVMCMed #Fever ... #Rash #Differential ... #Diagnosis #dermatology
Palpable Rash Algorithm

#Palpable #Rash #Algorithm #Diagnosis #Skin #Dermatology #Differential
Palpable Rash Algorithm ... #Palpable #Rash ... Diagnosis #Skin #Dermatology ... #Differential
Palpable Purpura - Rash Algorithm
#Diagnosis #Dermatology #Rash #Palpable #Purpura #Differential #Algorithm
Palpable Purpura - Rash ... Algorithm #Diagnosis #Dermatology ... #Rash #Palpable ... #Purpura #Differential
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
Pediatrics Patient - Differential ... Suggestive of: Rheum Fever ... Suggestive of systemic ... gabrieltalledop #dermatology ... arthritis #skin #differential
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... arthritis, Skin rash ... fraction < 20% Differential ... solid cancers • Systemic ... diagnosis #management #treatment
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH 
Vesiculobullous rashes provoke significant angst
in many physicians (Figure 5, page
However, the differential ... vesiculobullous rash ... and a fever may ... localized lesions and fever ... #Diagnosis #Dermatology