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Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... • Acute DIC - Septic ... comparison #diagnosis #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
inhibitor • Liver ... elevated in: • Heparin ... Thromboplastin #laboratory #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
symptoms, elevated liver ... A liver biopsy can ... and hematologic ... hemochromatosis; HIC, hepatic ... diagnosis #management #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... DIC • Severe Liver ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... • Reduced liver ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... cause e.g. heparin ... Reduced liver synthesis ... #differential #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... cardiac valves (septic ... Hyperhomocysteinemia - Heparin-induced ... pathophysiology #hematology
Hepatic Masses on MRI - Differential Diagnosis by MRI Findings Masses: Hemangioma, Adenoma, FNH, HCC, Fibrolamellar HCC,
Hepatic Masses on ... Venous, Delayed, Hepato-Biliary ... CBarreraMD #Hepatic ... differential #diagnosis #liver ... #hepatology #radiology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... deficiency • Liver ... the PTT suggests liver ... Acquired: • Liver ... Differential #Diagnosis #Hematology
Ammonia Levels & Hepatic Encephalopathy in Patients with Chronic Liver Disease Choosing Wisely: Things We Do
Ammonia Levels & Hepatic ... Patients with Chronic Liver ... ammonia-levels-and-hepatic-encephalopathy-patients-known ... TWDFNR #Diagnosis #Hepatology
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