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diagnosis management lupus sle erythematosus syndrome activation autoimmune cerebritis classification coagulation comparison dic differential disseminated druginduced hodgkins intravascular lymphoma macrophage
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... Cerebrovascular Disease ... autoantibodies that will cause ... #neurology #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
How? ... (CNS) dysfunction ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 60-80% - Low ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... months to years) Systemic ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • 8%-27% for CNS ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... Thromboembolism (7%) • CNS ... • Severe Liver Disease ... Treat primary cause ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Cough • Dyspnea ... may be high or low ... number of sites of disease ... Hodgkin Lymphoma Treatment ... classification #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... or ALS • Very slow ... • Conduction system ... statins - probably caused ... Myositis #Myopathy #rheumatology
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