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diagnosis management lupus sle syndrome blood differential erythematosus oncology reactions systemic workup activation algorithm antinxp2 antinxp2dm cardiology cardiomyopathy cerebritis cirrhosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Positive in 60-80% of cases ... 60-80% - Low ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
protease activity - A low ... hallmark for the disease ... If the value is low ... Fibrin degradation products ... Diagnosis #Workup #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
How? ... Fibrin degradation products ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Better call hematology ... levels: realllly low ... - Some tumors produce ... As with many disease ... Algorithm #workup #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... Presents as dyspnea ... Hypothermia: Due to low ... diagnosis #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... Puncture, EEG Treatment ... #rheumatology # ... diagnosis #management #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... 60-80% - Low ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Pulm: Hypoxia, dyspnea ... , Elevated Cr, Low ... calcium • Treatment ... diagnosis #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... Presents as dyspnea ... Hypothermia: Due to low ... diagnosis #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
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