16 results
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... • SPS - Sodium ... treatment #pharmacology ... #table #comparison ... #nephrology
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
#Binding #KBinders ... Kayexelate #Comparison #Table ... #Pharmacology # ... Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison ... #binders
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... Fluids Shift potassium ... 90 minutes) • Sodium ... LouLectures #Hyperkalemia ... #nephrology
Phosphate Binders - Pros and Cons

Calcium carbonate (TumsTM) 
 - Most inexpensive, antacid properties useful for
Low pill burden. ... edgarvlermamd - Nephrology ... #Table #Comparison ... #Pharmacology # ... Nephrology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... - Hyperkalemia ( ... Because digoxin binds ... , in states of hypokalemia ... (or low potassium
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Inexpensive - Treats hypocalcemia ... edgarvlermamd - Nephrology ... #Table #Comparison ... #Pharmacology # ... Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... alkalosis • Normal or low ... (renal potassium ... Rhabdomyolysis Treatment ... Syndrome #diagnosis #nephrology
Algorithm for Management of Acute and Chronic Hyperkalemia
Acute Hyperkalemia:
 - IV calcium (10 mL of 10%)
in 4 mL) - IV sodium ... - Consider K+ binders ... mL/min) - Oral sodium ... Acute #Chronic #treatment ... #nephrology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... 130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... decreased renal blood flow ... NS #comparison #pharmacology