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Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... • Evidence of glomerular ... → Refer to Nephrology ... for renal biopsy ... Diagnosis #Algorithm #Workup
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... (Pulmonary and renal ... sclerosis • Anti-Glomerular ... out infection, biopsy ... differential #diagnosis #nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... basement membrane disease ... disease Renal ... cancer • TURP/Biopsy ... causes #urology #nephrology
Renal Biopsy - Absolute and Relative Contraindications
WHEN NOT TO DO IT:
 • Isolated glomerular hematuria, unless
Renal Biopsy - Absolute ... : • Isolated glomerular ... progressive • Low ... hematuria or systemic disease ... Contraindications #management #nephrology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... mononeuritis multiplex WORKUP ... Diagnosis of PRS: Biopsy ... hypercellular glomeruli
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
negative if on low-gluten ... expensive Small bowel biopsy ... endoscopy and biopsy ... Tests #Diagnosis #Workup ... #Table
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
disease 24- ... in monitoring low-level ... disease. ... #testing #workup ... nephrotic #nephritic #nephrology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
disease 1) 24- ... in monitoring low-level ... #glomerular #disease ... #workup #diagnosis ... initial #testing #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
reabsorption) Workup ... 15 suggests ↓ renal ... Elimination (see Table ... acidosis) • Low ... Treatment #potassium #nephrology