1982 results
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
the population Disease ... decades of life Causes ... and clinical associations ... fever, fatigue, Nausea ... infiltration (lymphocytes
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Chronic lung disease ... Granulomatous disease ... Granulomatous lymphocytic ... DDX - Other causes
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... Xerostomia • Dental caries ... UIP, NSIP): • Lymphocytic
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... rnature-appearing lymphocytes ... 500/uL clonal B lymphocytes ... immunophenotype Clinical ... chemotherapy for low-risk disease
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... • Chronic Lymphocytic ... Leukemia (CBC with Lymphocytes ... - Monoclonal Lymphocytes ... Diagnosis #Algorithm #Causes
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... Pathogenesis and Clinical ... Findings B & T lymphocyte ... hyperplasia Note: B & T lymphocytes
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
super-antigen mediated disease ... Transverse Myelitis - Clinical ... Pleocytosis: Mild lymphocytic ... Pallidum - Lyme Disease ... MCTD - Bechet disease
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Cancer affecting lymphocytes ... cell neoplasm • Lymphocytes ... Orange or Hep C Clinical ... cells can indicate disease
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
hypereosinophilia (HE) Caused ... cytokines Common causes ... Rare causes: ... , IgG4-related disease ... Differential #Diagnosis #Causes
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
, and bandlike lymphocytic ... Although the cause ... an autoimmune disease ... more extensive cases ... #NEJM #clinical