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diagnosis differential oncology management lymphocytic thrombocytosis approach common cvid enlarged gap globulin hemeonc hodgkins hypogammaglobulinemia immunodeficiency lymphoma mcv mds myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... #Chronic #Lymphocytic ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... - infiltrates (anemia ... (Chronic Lymphocytic ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia ... #Causes #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... in adults • Disorder ... #Chronic #Lymphocytic ... #hematology #hemeonc
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... of Chronic Disease ... • Bleeding • Hemolysis ... of Chronic Disease ... #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
• Lymphoma • Leukemia ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... Cell Disease (children ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... inflammatory disorders ... myeloid leukemia ... #hematology #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Consider sickle cell ... Consider RBC membrane disorder ... #workup #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • Anemia of Chronic ... Disease • Marrow ... #Classification ... #Causes #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... #hematology #diagnosis
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