5 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation ... Syndrome in APML ... ATRA treatment Pathophysiology ... initiation • Differential ... #diagnosis #management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Edema in 70% of cases ... Atypical Lymphocytes ... Resolution > 15 days Differentials ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
impaired B-cell differentiation ... Granulomatous lymphocytic ... DDX - Other causes ... : • Nephrotic syndrome ... #diagnosis #management
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
Lymphocytopenia DIAGNOSTIC ... mL or 20% total lymphocyte ... chemotherapy) • Genetic syndromes ... #hematology #Differential ... #Causes #lymphocytopenia
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
(HES) - Diagnosis ... and Management ... eosinophilia Secondary Causes ... Myeloproliferative HES - Lymphocytic ... #hematology #differential