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diagnosis differential hematology management oncology algorithm cardiology comparison hypertension leukemia lupus msk secondary sle systemic aorticregurgitation approach arthritis biliary cholangitis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Cancer affecting lymphocytes ... cells can indicate disease ... Leukemia #diagnosis #workup ... #oncology #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... fever, fatigue, Nausea ... infiltration (lymphocytes ... Urticaria #diagnosis #rheumatology ... #comparison #table
Chest Pain - Differential Diagnosis Algorithm Cardiovascular Causes: - Outflow Obstruction • Aortic
Infarction • Stable ... Gastro-Esophageal Reflux Disease ... • Biliary Disease ... • Peptic Ulcer Disease ... Radiculopathy #ChestPain
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... PT, aPTT(liver disease ... bypass), LFT (liver disease ... patients if the cause ... #Workup #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... extramedullary disease ... -> AML: Blast crises ... CLL (Chronic Lymphocytic ... #Leukemia #Hematology
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing Common causes: • Renal parenchymal disease
Renal parenchymal disease ... of renal disease ... • Renovascular disease ... #Screening #Workup ... #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology: • T lymphocyte ... intralobular bile ducts causes ... but elevated as disease ... , IgG4 related disease ... cholangitis #diagnosis #workup
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung disease ... Granulomatous disease ... Granulomatous lymphocytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... Management #Summary #rheumatology
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