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diagnosis hepatology differential algorithm causes cirrhosis injury biliary lfts acute ah aih autoimmune cholangitis criteria hepatocellular hepatomegaly liverenzymes pbc primary
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Hepatitis (AH) ... • Onset of jaundice ... ) or metabolic liver ... disease (Wilson ... Possible drug-induced liver
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
of Autoimmune Hepatitis ... - Onset of jaundice ... ) or metabolic liver ... disease (Wilson ... Possible drug-induced liver
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
HSV • Toxic: Alcohol ... Hemochromatosis, Wilson's ... Disease, Alpha- ... Syndrome, Celiac Disease ... Medication, Pregnancy, Alcoholic
Clinical Examination for Liver and Biliary Diseases 1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... Xanthelasma and jaundiced ... Kayser-Fleischer rings in Wilson's ... Edema #biliary #physicalexam ... #cirrhosis #liver
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • NAFLD • Alcohol ... • Cholestatic disease ... Ducts • PSC • Alcoholic ... hepatitis • Drugs
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's ... Disease • Amyloidosis ... Inflammatory • Alcoholic ... Induced Hepatitis
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Sarcoidosis Toxic - Alcohol ... Nonalcoholic fatty liver ... disease - Wilson
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 Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... Drugs (MDMA), Alcohol ... Hemochromatosis, Wilson's ... disease, Alpha- ... HELLP, Celiac disease
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Metabolic/Hereditary: Wilson ... ALT Ratios: • Alcoholic ... liver disease: ... Chronic viral hepatitis ... #injury #hepatitis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology: • T lymphocyte ... cholestasis → Cirrhosis/Liver ... hyperpigmentation • Jaundice ... or higher • Liver ... Diagnosis: • Viral hepatitis
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