12 results
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
QD (adjust dose at ... calcium for K; also binds ... nonspecifically binds ... #pharmacology #table ... #comparison #binders
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
Potassium #Binding #KBinders ... #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia
Phosphate Binders - Pros and Cons

Calcium carbonate (TumsTM) 
 - Most inexpensive, antacid properties useful for
Phosphate Binders ... ; may have ancillary ... ; may have ancillary ... pill burden - May ... #Table #Comparison
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #Management #Hyperkalemia ... #pharmacology #table ... #comparison #nephrology
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Used Phosphate Binders ... Lower risk of hypercalcemia ... absorption of iron that may ... #Phosphate #Binders ... #Table #Comparison
Algorithm for Management of Acute and Chronic Hyperkalemia
Acute Hyperkalemia:
 - IV calcium (10 mL of 10%)
Algorithm for Management ... - Consider K+ binders ... bicarbonate - Consider binders ... (may facilitate ... #Algorithm #Management
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Lactated Ringers ... Saline (NS) - Comparison ... Is Dangerous in Hyperkalemia ... excretion • Saline May ... Normal #Saline #NS #comparison
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antibodies bind to mast ... specific allergen binds ... or IgM antibody binds ... Classification #Pathophysiology ... Diagnosis #Reactions #Table
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... transfusion • Pathophysiology ... • Criteria - At ... hematology #diagnosis #comparison ... #table
Medications for the Treatment of Hyperkalemia
The goals of acute treatment are to prevent potentially life-threatening cardiac
the Treatment of Hyperkalemia ... because treatment may ... because patients are at ... Figure 3 is an algorithm ... , and Table 3 summarizes