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diagnosis nephrology causes hyperkalemia algorithm hematology high management pathophysiology sle alkalosis ammonia chloride disorders diuresis diuretics druginduced encephalopathy erythematosus excretion
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
and probably < ... Best indications ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Chloride Algorithm Cl ... Kidney loss of Cl ... alkalosis • Loss of Cl ... Cystic fibrosis Cl ... potassium acid
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... La, anti-Jo-1, SCL ... /or medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... transfusion • HTN and ... • NSAIDs • ACE ... infusions) - Metabolic ... Medications 2.
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... transfusion • HTN and ... • NSAIDs • ACE ... infusions) - Metabolic ... Medications 2.
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
decreased metabolism ... ileal conduit - Medications ... Multiple myeloma, CML ... , AML - Large ... Hyperammonemia #Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... family history - Medications ... function test, ANA ... changes), high MCV ... not required in all
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... Evans • ITP • Cl-NH ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Diuretics and Agents ... resistance • Metabolic ... +K+2Cl- Symport ... Diuresis #Nephrology #Pharmacology ... #Medications #Table
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