11 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... from antibodies formed ... Anticardiolipin antibodies (aCL ... Antiphospholipid #Syndrome ... #management #anticoagulation
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
that are poorly formed ... or don’t work properly ... Workup: • Complete ... #diagnosis #hematology ... #oncology
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
its Chloride (Cl ... are balanced by Cl ... high amount of Cl ... #foamed #criticalcare ... #management #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
(HCV) • CLL & MBL ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Differentiation #Syndrome ... #management #hematology ... #oncology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... days → add fungal work-up ... ): - Hematologic ... fluids (200–300 mL ... #HemeOnc #Diagnosis
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
hormones that work ... for Refeeding Syndrome ... #diagnosis #differential ... #algorithm #management ... #foamed
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
acute coronary syndrome ... #algorithm #management ... treatment #table #foamed ... heartfailure #chf #criticalcare ... icu #clinical #pharmacology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... • Diagnosis of ... irrigation • Management ... Inhibitors of Na+K+2Cl ... Diuresis #Nephrology #Pharmacology