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hematology management differential lupus sle syndrome erythematosus leukemia pediatrics signs chronic cll comparison disorders hodgkins lymphocytic lymphoma monoclonal testing thrombocytopenia
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing ... #workup
Osteosarcoma Most common primary malignant bone tumor in children Most Common Sites of Involvement: 1. Distal femur
proximal femur Clinical ... after injury • Systemic ... symptoms generally ... #Features #Oncology ... #Peds #Pediatrics
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... likely it will be clinically ... • Homogeneous: Systemic ... ANA #patterns #rheumatology ... #diagnosis #differential
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... Differential Diagnosis ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... pain (20%) Renal disease ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... - Differential Diagnosis ... Ig deposition disease ... #Differential #Diagnosis ... #hematology #oncology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... Evolution: Chronic disease ... Management #Summary #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
fever syndromes Clinical ... Fever is the main clinical ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... association • M > F Clinical ... CNS symptoms (headache ... Behcet syndrome (Clinical ... #rheumatology #
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