21 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Causes of false- ... amyloidosis Other causes ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
Causes of Pleural ... • Pulmonary embolism ... Gastrointestinal disease ... Diagnosis #Algorithm #Hepatology ... #causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... • Cholesterol emboli ... • Septic emboli ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
chronic kidney disease ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... differential #diagnosis #causes ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Corpuscular Volume (MCV ... Myelodysplastic Syndromes ... • Liver Disease ... #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... Petechial or purpuric rash ... 5000 to 10,000 ng/mL ... Diagnosis #Management #Hematology ... #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
(HCV) • CLL & MBL ... • Heavy Chain disease ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... - Rash: multiple ... Causes: - Idiopathic ... , breast CA - Hematologic ... #oncology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
thrombophlebitis, pulmonary emboli ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... DIC • Septic emboli ... #hematology