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management hemeonc leukemia monoclonal rheumatology chronic differential differentiation emergencies erythematosus gammopathies hemophagocytic hlh lupus lymphocytic lymphohistiocytosis macrophage mas mds mgus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
/min A - Anemia ... M spike: • CML ... diseases, CML, ... plasmacytoma, POEMs syndrome ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... • Neutropenia, anemia ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... #APML #diagnosis ... #management #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
transformation to AML ... Myelogenous Leukemia (CML ... progression to AML ... #diagnosis #hematology ... #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Petechial or purpuric rash ... with leukopenia, anemia ... 5000 to 10,000 ng/mL ... #Syndrome #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Evans • ITP • Cl-NH ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Malignancy (e.g. hematologic ... lymphopenia, low PLT • Anemia ... La, anti-Jo-1, SCL ... activation and/
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
): - Hematologic ... fluids (200–300 mL ... - CRS: fever, rash ... ± tocilizumab; call ... #HemeOnc #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
with the HLH syndrome ... Syndrome) 3. ... - Cytopenias (anemia ... Pathophysiology ... #Management #Hematology
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