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diagnosis rheumatology dermatology treatment disease syndrome lupus monoclonal prevention sle systemic adult anemia antinxp2 antinxp2dm aosd aplastic atopic behcet behcets
Leser–Trélat Sign on Physical Exam Acute onset of multiple seborrheic keratoses, often a paraneoplastic sign of malignancy. #Leser
PhysicalExam #clinical #video ... #skin #dermatology ... #oncology
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 Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
/dL or CC < 40 ml ... M spike: • CML ... POEMs syndrome, Castleman's ... MGUS #diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... component+neuropathy+Castleman ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
• Absence of skin ... Mean eGFR - 39.5 mL ... /min • <60 mL/ ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology #
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
refractory disease Skin ... Syndrome #Treatment #management ... #pharmacology # ... rheumatology
Atopic Dermatitis - Topical Treatment Options First Line: Topical Corticosteroids - High Potency: Betamethasone
After non-pharmacologic ... very different skin ... #Medications #Pharmacology ... #Dermatology #Management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Overview: ALL, CML ... involvement CML ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
response to local skin ... retinal damage) • Skin ... test (this is a skin ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Malignancy (e.g. hematologic ... Interferonopathies • Castleman's ... Seizures • Strokes Skin ... La, anti-Jo-1, SCL
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