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diagnosis dermatology myelodysplastic rheumatology algorithm behcet chronic clinical cll cutaneous eosinophilia erythematosus immunology lupus lymphocytic manifestations mds monoclonal myelodysplasia paraproteinemias
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Eosinophilia - Differential ... • Eosinophilic Leukemia ... GI, lung, skin), ... Heme malig (AML, CML ... , Sarcoidosis, SLE
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... dermatomyositis, SLE ... #differential # ... #oncology #clinical ... #skin
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Hematology #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
) Differential Diagnosis ... Oral aphthae : SLE ... tears, Ischemia, Leukemia ... • Arthritis: SLE ... #diagnosis #management
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... , breast CA - Hematologic ... - Allergic contact ... - Lupus - Leukemia ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Hepatomegaly • Skin ... cells can indicate disease ... diagnosis #workup #oncology ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Seizures • Strokes Skin ... La, anti-Jo-1, SCL ... Hodgkin lymphoma and leukemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Alpha & Mu) Skin ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
following: • Behcet Disease ... Chronic myeloid leukemia ... Pathergy #diagnosis #differential ... #allergy #immunology ... #dermatology #skin
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
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