17 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... cytopenias (usually anemia ... #Syndrome #MDS ... #treatment #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... multiple myeloma, myelodysplastic ... syndrome (MDS) ... syndrome (MDS) ... Autoinflammatory #Somatic #rheumatology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... diagnosis #causes #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... platelets) • MDS ... precursors MDS ... Myelogenous Leukemia (CML ... #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Corpuscular Volume (MCV ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... Algorithm #Causes #Hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Disorders - Myelodysplastic ... Pelger-Huet, Macrocytic anemia ... - Amy Chung, MD ... , MSc @AmyChung ... Blood #Disorders #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
• Hypocellular myelodysplastic ... syndrome (MDS) ... Hypocellular/Hypoplastic MDS ... #oncology #hematology ... #diagnosis #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Infection exposure (l MD ... SOAP) - Risks ... changes), high MCV ... anemia (vegan, ... Causes #Workup #hematology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
microangiopathic hemolytic anemia ... of arteries Management ... #rheumatology # ... nephrology #diagnosis ... #management