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diagnosis causes sle algorithm erythematosus hemolysis systemic anemia blood deficiency druginduced drugs extravascular g6pd hcq hemolytic hydroxychloroquine intravascular isolated levels
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... CD23, o CML ... Amy Chung, MD, MSc ... #hematology #Markers ... #Differential #
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Neutropenia - Differential ... Algorithm Congenital Medications ... Anticonvulsants • Antibiotics ... Destruction • Systemic Lupus ... Algorithm #Causes #Hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
probably < 1500ng/mL ... Best indications ... Measurement #SLE #rheumatology ... #pharmacology # ... levels #lupus #management
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... family history - Medications ... changes), high MCV ... #Differential # ... Causes #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... lymphoproliferative disorders ... Drugs (Beta lactam antibiotics ... Extravascular #Causes #differential ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... activation and/or medications ... Erythematosus #Diagnosis #Rheumatology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis - Chloroquine (Aralen)*
Medications to Avoid ... Macrodantin)* - Antibiotic ... #Differential # ... Diagnosis #Pharmacology ... #Hematology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... Erythematosus #medications ... #drugs #pharmacology ... #risk #differential ... #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Neutropenia • Platelet Disorders ... isoniazid) • Antibiotics ... blood count with differential ... Syndromes #diagnosis #hematology
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