15 results
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds ... #Febrile #Infant
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
acute or subacute febrile ... following: • Fever ... Ferritin >500 ng/mL ... • Bicytopenia Treatment ... #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... Imaging: CXR- pulmonary ... #management #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
: 33% • Treatment ... , and CXR with pulmonary ... edema) • Fever ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Diagnostic Criteria ... Syndrome (Acute Febrile ... Fever, temperature ... Excellent response to treatment ... #Hematology #Dermatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... : - If febrile ... Syndrome #TLS #diagnosis ... #management #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
extremities during febrile ... Ferritin >3000 ng/mL ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology #
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
- Nonremitting fever ... 5000 to 10,000 ng/mL ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
The Febrile Infant Step-by-Step Algorithm
This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... Management #Pediatrics #Peds ... Stratification #Fever
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
Algorithm regarding ... the diagnosis and ... treatment of Hereditary ... SF of >1,000 μg/mL ... #hepatology #gastroenterology