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diagnosis im management differential em algorithm clinical ddxof treatment cardiology causes nejm table hematology rheumatology nephrology pathophysiology pulmonary workup comparison
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... /dL) IgM MGUS, low-risk ... MGUS (IgG type, ... - protein <1.5 gm ... 8) light-chain MGUS
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
formation is common in IgM ... Rouleaux #formation #IgM ... #gammopathy #MGUS
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... MGUS: • Serum ... protein level (non-IgM
IgM and Non-IgM - Risk and Type of Progression #EBM #Honc #MGUS #Progression #IgM #NonIgM #MultipleMyeloma
IgM and Non-IgM ... Progression #EBM #Honc #MGUS ... #Progression #IgM
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Idiopathic monoclonal IgM ... Immunoglobulin M (IgM ... Infections: Polyclonal IgM ... Diagnosis Monoclonal IgM ... significance (MGUS
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... Dermato-neuro syndrome) MGRS ... anemia due to cold IgG ... anticoagulant • IgM
Monoclonal Gammopathy Testing Strengths, Weaknesses and Accuracy Compared - SPEP - IFE - FLC
Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... • Organized Ig ... w/ monoclonal Ig ... #Significance #MGUS
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... may be seen when IgM ... 2: Monoclonal IgM ... 25%): Polyclonal IgM ... 3: Oligoclonal IgM
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS
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