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hematology management oncology neurology algorithm monoclonal gammopathy classification disease joint monoarthritis monoarticular polyarthritis polyarticular significance signs syndromes agglutinin ana anemia
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... ) - Differential ... Renal-centered (ie "MGRS ... #Significance #MGUS ... Diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... ) MGRS: • Fibrillar ... #Monoclonal #Differential ... #Diagnosis #Oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... constitutional symptoms ... Light-Chain MGUS
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... arthritis - (Reiter’s syndrome ... should have other symptoms ... #msk #Differential ... #Diagnosis #Algorithm
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... significance (MGUS ... hemolytic #anemia #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... treatment of infective symptoms ... rituximab (in clinical ... high-risk situations #MGUS ... Complications #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... - Differential ... Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... - Coagulation disorder ... Wernicke-Korsakoff syndrome ... #diagnosis #signs ... #symptoms #nutrition
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
conjunction with symptoms ... MRI lesions and clinical ... consistent with MS ... noninflammatory #differential ... #diagnosis
Posterior Ankle Impingement (Os Trigonum) Syndrome - MSK Radiology Imaging Findings: • Os trigonum which has marrow
(Os Trigonum) Syndrome ... - MSK Radiology ... hallucis longus Differential ... flexion but no symptoms ... #diagnosis #msk
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