1539 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... (IgG type, M- protein ... diagnosis #management #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... IgM monoclonal protein ... Serum monoclonal protein ... Urinary monoclonal protein ... #Significance #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
gamma gap (total protein ... #Gammopathies #MGUS ... #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Feature A Monoclonal Protein ... • MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS ... Paraproteinemias #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Gap (Total Protein ... • (Total protein ... Gammopathy Include: • MGUS ... gastric tumors • Hematology ... differential #diagnosis #hematology
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Gammopathy #Testing #Protein ... #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
) MGRSMGRS ... meet criteria for hematologic ... or evolve into hematologic ... • Serum/urine protein ... after achieving hematologic
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS ... diagnosis #management #hematology
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Subtypes of Serum Proteins ... Retinol-binding protein ... Ceruloplasmin, Protein ... SatyaPatelMD #Serum #Proteins ... classification #Types #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... #Significance #MGUS ... Differential #Diagnosis #hematology