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nephrology diagnosis glomerulonephritis pathology clinical differential electronmicroscopy membranous mgn algorithm diseases glomerular rheumatology antibodies associations autoantibodies classification comparison glomerulus membranoproliferative
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... to Kidney: Anti-GBM ... involvement: Anti-GBM ... StanfordChiefs #RPGN
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Glomerulonephritis (MPGN ... Complement-Mediated MGPN ... , CFHR5 neph) MPGN ... immune deposits on EM ... Glomerulonephritis #MPGN
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Glomerulonephritis (RPGN ... Basement Membrane (GBM ... Linear, ribbon-like GBM ... staining on IF • No EM ... Glomerulonephritis #RPGN
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Electron Microscopy (EM ... GN • Amyloid RPGN ... • Anti-GBM disease ... pathology #comparison #table
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Cytomegalovirus; GBM ... atypical HUS; MPGN
Stage III Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM from a biopsy with membranous
acellular scanning EM ... more extensive GBM ... surface of reticular GBM ... glomerulonephritis #MGN ... #SEM #clinical
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 Stage II Membranous Glomerulonephritis on Electron Microscopy This eyeSCANdy image shows acellular scanning EM of a glomerulus
acellular scanning EM ... appearance of GBM ... glomerulonephritis #MGN ... #stage2 #GBM #ElectronMicroscopy ... #SEM #clinical
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 Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
(Diffuse) Anti-Sm ... Celiac disease Anti-GBM ... diseases #diagnosis #table
Stage IV Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM of glomerular capillary loops from
acellular scanning EM ... completely bridged GBM ... glomerulonephritis #glomerulus #MGN ... ElectronMicroscopy #SEM
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