3073 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... C-ANCA): GPA >>> MPA ... > eGPA • MPO-ANCA ... P-ANCA): eGPA, MPA
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... tract, and often causes ... (10-40% ANCA +MPO
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... - pANCA anti-MPO ... Discontinuation of causal ... Positive in 60-80% of cases ... - pANCA anti-MPO
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
myeloperoxidase (MPO-ANCA ... present in > 30 / MPO ... infiltrates, hemoptysis, MPO ... tract, and often causes ... 40 Y / ANCA + MPO
Monkeypox

What?
Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus
Viral zoonotic disease that is
disease that is caused ... with someone with Mpox ... with confirmed mpox ... lesions develop crusts ... #Monkeypox #MPOX
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... polyangiitis - MPO ... PR3 (80-90%) > MPO ... Churg-Strauss) - MPO
Drugs Causing Acute Pancreatitis

Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... and atleast4 case ... #Pancreatitis #Causes
Abnormal Lipid Profiles - Differential Diagnosis Algorithm

Increased Cholesterol and Triglycerides 
 - Genetic Causes
- Secondary Causes ... HDL - Genetic Causes ... • Apo-A1 Deficiency ... - Secondary Causes ... Deficiency • Apo-Cll
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... found in 60% of cases ... Nodosum #Mnemonic #Causes