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Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... - pANCA anti-MPO
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... - pANCA anti-MPO ... 40, F:M 9:1 • Clinical ... - pANCA anti-MPO
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
C-ANCA): GPA >>> MPA ... > eGPA • MPO-ANCA ... P-ANCA): eGPA, MPA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
Differential Diagnosis MPA ... 50% P-ANCA (MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
a.k.a EPO. ... waiting for the EPO ... is ramping up EPO ... vs exogenous, EPO ... tumors produce EPO
Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV =
Loop diuretic PO ... Furosemide 40 mg PO ... Torsemide 20 mg PO ... Bumetanide 1 mg PO ... Recommended Text: Clinical
Loop diuretic conversion - Equivalent Doses Furosemide (Lasix) 40 mg PO = Furosemide 20 mg IV =
(Lasix) 40 mg PO ... Torsemide 20 mg PO ... Bumetanide (Bumex) 1 mg PO ... Recommended Text: Clinical
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