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Outpatient Treatment of with Community-Acquired Pneumonia (CAP)
No comorbidities or risk factors for MRSA or Pseudomonas aeruginosa:

Community-Acquired Pneumonia (CAP ... doxycycline or • macrolide ... cephalosporin AND macrolide ... IDSA #Outpatient #CAP

CAP, HCAP, HAP and VAP - Diagnosis and Treatment

HCAP & CAP – those presenting to the

CAP, HCAP, HAP and ... VAP - Diagnosis ... & CAP – those presenting ... twitter.com/foamid #CAP ... #HCAP #HAP #VAP

Antibiotics for Atypical Bacteria
- Macrolides (Azithromycin)
- Tetracyclines (Doxycycline)

Atypical Bacteria - Macrolides

Antibiotic Classification by Mechanism of Action

Cell Wall Synthesis:
Penicillins
Cephalosporins
Carbapenems
Monobactams
Beta-lactamase inhibitors
Glycopeptides

Protein

Cloramphenicol Macrolides

Antibiotics and CNS Diffusion

1. Drugs with good CNS diﬀusion:

- Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole

2. Drugs

Echinocandins, Macrolides

Azithromycin - since there has been a lot of noise around chloroquine/hydroxychloroquine, thought we can take

hydroxychloroquine, thought we can ... Azithromycin #Zithromax #Macrolides

Drugs associated with worsening of Myasthenia Gravis (MG):
• D-penicillamine
• Botulinum toxin.
• Telithromycin
• Fluoroquinolones
• Quinine
• Magnesium
• Macrolide antibiotics
• Corticosteroids (may cause transient

• Magnesium • Macrolide ... Patients with MuSK-MG ... muscle-specificreceptortyrosinekinase #AChR #MuSK

Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
• Most common cause of:

common cause of: CAP ... Urine antigen in CAP ... sensitive) • Macrolide

Classification of Some Antimicrobial Agents by Their Sites of Action
Inhibitors of metabolism: Sulfonamides, Trimethoprim
Inhibitors of cell

Aminoglycosides, Macrolides

Antibiotics - Mechanisms and Sites of Action

Inhibit Cell Wall Synthesis or Function
- Beta Lactams,

50S subunit - Macrolides

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