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diagnosis management hematology differential syndrome anemia oncology algorithm disease lupus neurology abnormal clinical coagulation criticalcare hemolytic hemophagocytic hemorrhage hlh lymphohistiocytosis
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Evidence Summary for Transfusion ... unnecessary and cause ... Transfusions should ... Transfusions are ... #Thresholds #Hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
TRALI vs TACO - Transfusion ... without other cause ... : 33% • Treatment ... : No • Treatment ... #Reactions #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Post-abortion Hemorrhage Management Algorithm Cervical laceration → Direct pressure, silver nitrate for small laceration → Repair with
atony or unsure of cause ... → Fundal massage ... Care team for massive ... transfusion protocol
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Treatment of Thrombotic ... HUS) Treatment ... Contraindication to platelets transfusion ... #rheumatology # ... hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Anemia Intrinsic Causes ... elliptocytosis Extrinsic Causes ... Intravascular Causes ... prosthetic valve • Transfusion ... classification #hematology
Thromboelastography (TEG) based therapy and Management If r time prolonged -> FFP If MA low -> plts/cryoprecipitate (if
50 - > platelet transfusions ... Management #Diagnosis #Hematology ... Thromboelastogram #Treatment
Thromboelastography (TEG) Based Management - If R time prolonged -> FFP - If MA low
50 -> platelet transfusions ... TEG #Management #treatment ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... HUS) • Other: Transfusion ... implicated) - Transfusion ... Extravascular #Causes ... differential #diagnosis #hematology
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