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differential algorithm causes management pancytopenia ascorbicacid calculation cobalamin index mds myelodysplasia myelodysplastic neutropenia oncology platelets production reticulocyte scurvy syndromes vitamin
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
- Differential Diagnosis ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Inflammatory: • IBD ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... • Folate deficiency ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Acute hemolysis, deficiency ... anemia, Rebound ... effect from treatment ... Vasculitides, IBD
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Factor The maturation ... loss), Vitamin B12 ... , Folate • Hormone ... Production #Index #hematology ... #diagnosis #calculation
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... diarrhea related to IBD ... Check for IF ab Treatment ... #Cobalamin #Deficiency ... #nutrition
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... ) - Diagnosis and ... lead to iron and folate ... vasculitis Treatment ... #Nutrition #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... • Copper deficiency ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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