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diagnosis management syndrome algorithm anemia aplastic apml causes chronic cll coagulation dic differential differentiation disorders disseminated hodgkins intravascular leukemia leukostasis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Responsive to Treatment ... growth, response to treatment ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #Hematology #Diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
anemia, GATA2 deficiency ... , CTLA4 deficiency ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... thrombopoietin deficiency ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
-95% of cases) Classification ... Hodgkin Lymphoma Treatment ... lymphoma #diagnosis #classification ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
or folic acid deficiency ... factor (GCSF) treatments ... • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
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