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differential causes oncology leukemia algorithm cd4 chronic common cvid hypogammaglobulinemia icl idiopathic immunodeficiency immunology lymphocytopenia lymphopenia management mds myelodysplasia myelodysplastic
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Secondary Thrombocytosis ... malignancies • Anemia ... specifically: iron deficiency ... Myelodysplastic syndrome ... #Causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
phases of maturation ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... anemia, Rebound ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... formed or don’t work ... DDX: Rule Out Secondary ... #diagnosis #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
underlying primary or secondary ... mL or 20% total lymphocyte ... chemotherapy) • Genetic syndromes ... variable immune deficiency ... #hematology #Differential
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... Granulomatous lymphocytic ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... - Copper deficiency-rare ... #causes #hematology
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