12 results
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
Patients with cirrhosis ... and hematologic ... If other causes ... saturation. ... diagnosis #management #hepatology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... Renal Disease, Liver ... Reticulocytosis • Liver ... #Hematology
Causes of Hyperferritinemia - Differential Diagnosis
Ferritin > 1000
Ferritin is the storage form of iron. Increased hepcidin
is made in the liver ... Hematologic Malignancy ... Check the iron saturation ... Sideroblastic anemia ... use can mimic hemochromatosis
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... Microcytic" • Iron ... : Alcohol use, Liver ... differential #diagnosis #causes ... #hematology
Vibrio Vulnificus skin infection
Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. 
Vibrio vulnificus part of
skin infection Cirrhosis ... marine microbiota & causes ... /hemochromatosis ... , hemolytic anemia ... rash #cellulitis #dermatology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Spoon-shaped • Iron ... deficiency anemia ... discoloration) • Liver ... cirrhosis • Congestive ... Systemic #Secondary #dermatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... synthesized in: liver ... • Pernicious anemia ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... DIC • Severe Liver ... Treat primary cause ... treatment #management #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... disease • Liver ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Sarcoidosis) • Liver ... disease: Cirrhosis ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology