Maturation iron pathophysiology hematology cirrhosis liver pbc rbc cbc gastroenterology antibodies hepatology algorithm causes primary

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Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison

Cholestatic Liver ... Disease: Primary ... Biliary Cirrhosis ... Cholangitis #pathophysiology ... #pbc #psc #hepatology

Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
• Female:Male 9:1
• Common European descent
• Age:

Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... PBC Signs and ... diagnosis #workup #hepatology

Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:

pregnancy Diagnose PBC ... Liver biopsy findings ... consistent with PBC ... #PBC #Primary ... #hepatology

Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
- Decreased/NormaI

Reticulocytosis • Primary ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... • Early Iron ... #Causes #Hematology

Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
• Artifact (redo CBC)
Autonomous:
• Essential thrombocytosis
• Polycythemia

Causes of Thrombocytosis ... Artifact (redo CBC ... Myelogenous Leukemia • Primary ... malignancy • Iron ... #Causes #Hematology

Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
•

Causes of Anemia ... Neutrophils - Low RBC ... B12 - Anti-IF Antibodies ... Pernicious Anemia RBCs ... #Causes #Hematology

Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury:
• Hepatic vein:

stone, Malignancy, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #hepatology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

decreased PLT count: CBC ... anti-phospholipid antibodies ... disease), HBsAg/anti-HBc ... unclear, or if a primary ... #Workup #hematology

Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
- Enzymes that catalyze hydrolysis of organic phosphate

Differential Diagnosis Algorithm ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis (PBC ... #hepatology

Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH.

Step 1: In the patient with

Algorithm regarding ... Patients with cirrhosis ... saturation. ... diagnosis #management #hepatology ... #gastroenterology

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