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differential management syndrome algorithm bandemia basophilia basophils cbc coagulation dic disseminated erythematosus fungal gap globulin hepatology hepatopulmonary hps infections infectiousdiseases
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... disorders • Celiac disease ... malignancy • Iron ... #Hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
- Differential Diagnosis ... Colitis and Crohn’s Disease ... : • Iron deficiency ... Irradiation • Cirrhosis ... #causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... count ↑ PLT • ↑ PBS ... all phases of maturation ... #Hematology #Oncology ... #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Hodgkin lymphoma and leukemia ... #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Tissue damage • Leukemia ... • Autoimmune diseases ... #CBC #hematology ... #pathophysiology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... ferritin level, and iron ... (to support a diagnosis ... ANA and RF (if clinical ... #testing #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
(RA, Temporal arteritis ... : Cirrhosis, ETOH ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... Sjogrens #Syndrome #Rheumatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
abnormalities PATHOPHYSIOLOGY ... arteriovenous shunting causes ... of orthodeoxia CLINICAL ... • Stigmata of cirrhosis ... #diagnosis #hepatology
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