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algorithm bandemia basophilia cbc coagulation dic disseminated erythematosus gap globulin intravascular laboratory lupus management neutrophil oncology protein proteingap rheumatic rheumatoid
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... : • Iron deficiency ... Irradiation • Cirrhosis ... Diagnosis #causes ... #hematology #basophils
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... disorders • Celiac disease ... malignancy • Iron ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... all phases of maturation ... eosinophilia, basophilia ... #Hematology #Oncology ... #Diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Tissue damage • Leukemia ... • Autoimmune diseases ... #WBC #CBC #hematology ... #pathophysiology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Hodgkin lymphoma and leukemia ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
(RA, Temporal arteritis ... : Cirrhosis, ETOH ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... ferritin level, and iron ... (to support a diagnosis ... ANA and RF (if clinical ... #testing #Rheumatology
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