12 results
An Approach to Jaundice Workup Algorithm by CBC and LFT Pattern

- Dr. Eric Strong @DrEricStrong

#Jaundice #Workup
Approach to Jaundice Workup ... Algorithm by CBC ... and LFT Pattern ... #LFTs #Diagnosis ... #Hepatology #Differential
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
/uL Initial Workup ... : CBC with diff, ... LDH, ESR, CRP, iron ... ↓ Production (↓ ... #hematology #workup
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... deficiencies: Iron ... #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... Diagnosis Algorithm ... MCH, MCHC, Serum Iron ... Production - Normal ... #Causes #Hematology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... Ducts - PBC ... Congenital, Others, Cirrhosis ... #hepatology #LiverFunctionTests
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... Pathophysiology ... bile ducts Differential ... #diagnosis #workup ... #hepatology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
- Differential ... LOW RETIC INDEX ... - ↓ PRODUCTION ... Alcohol related, Iron ... Diagnosis #Hepatology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... erythropoietin (EPO), iron ... substrate (e.g. iron ... OR reticulocyte index ... #Workup #Hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
extrahepatic source Production ... hepatitis: < 1 • Cirrhosis ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Better call hematology ... else is driving RBC ... production - EPO-dependent ... #workup #hematology