23 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver Disease ... : Primary Biliary ... Cirrhosis vs Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Cirrhosis - Pathophysiology ... relative with PBC ... Cholestasis #PBC ... #Cirrhosis #Pathophysiology ... #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Thalassemia, Iron ... deficiency anemia ... anemia (sometimes ... elliptocytosis, Severe iron ... differential #diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
x (Hct / 45) / Maturation ... Factor The maturation ... deficiencies: Iron ... Chronic kidney disease ... Production #Index #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... MCH, MCHC, Serum Iron ... Reticulocytes • Iron ... Disease • Marrow ... Algorithm #Causes #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Cirrhosis (PBC) ... Pathophysiology ... #Cirrhosis #PBC ... diagnosis #workup #hepatology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... • Microcytic - Iron-deficiency ... , Thalassemia, Iron-deficiency ... coagulopathy (DIC) #RBC ... #differential #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... disorders • Celiac disease ... malignancy • Iron ... deficiency anemia ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... inflammation) • Iron ... Spherocytosis, G6PD, PK, HbC ... Non-megaloblastic: Liver disease ... Differential #Diagnosis #hematology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Spoon-shaped • Iron ... deficiency anemia ... discoloration) • Liver cirrhosis ... Systemic #Secondary #dermatology