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differential algorithm hemolytic causes extravascular intravascular atypical dermatology ferritin iron nonpalpable palpable purpura rheumatology schistocytes syndrome testing uremic workup
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
syndrome (ST-HUS ... known as atypical HUS ... • Severe B12 deficiency ... anemia" • HELLP ... #hematology #hemolysis
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Atypical HUS - Hemolytic ... Unlike typical HUS ... still present with anemia ... JustinMD19 #Atypical #HUS ... #aHUS #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... DIC, TTP, HELLP, HUS ... , aHUS, mechanical ... #workup #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • PK deficiency ... anemia • ... MAHA (TTP, DIC, HUS ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... uremic syndrome (HUS ... G6PD deficiency) ... #hematology #anemia
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... extravascular) hemolysis ... athletic training, Pulmonary ... diet, Alcoholism, Tea-toast ... #ferritin #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disease - DIC/TTP/HUS ... - Hemolytic ... anemia - Splenomegaly ... : • DIC, TTP/HUS ... necrosis) • VIT K deficiency
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